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Bed Bug Control With IGR Insect Growth Regulators Juvenile Hormones and chitin synthesis inhibitor.
What works, what dosnt work and what shows promise.
Krüppel homolog 1 and E93 mediate Juvenile hormone methoprene regulation of metamorphosis in the common bed bug, Cimex lectularius
We studied the regulation of molting and metamorphosis in bed bugs with a goal to identify key players involved.
Methoprene induced Kr-h1 and suppressed E93 and induced formation of the supernumerary nymph.
These data show interactions between Kr-h1, E93 and JH in the regulation of metamorphosis in the bed bugs.
https://www.nature.com/articles/srep26092?WT.feed_name=subjects_zoology
The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Krüppel-Homolog 1 and Broad-Complex
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006020
Efficacy of (S)-methoprene against Cimex lectularius (Hemiptera: Cimicidae).
A dose of 30 mg/m2 has been shown to interrupt the development of susceptible bed bugs in laboratory experiments. The efficacy of (S)-methoprene was assessed against both a laboratory susceptible strain and a field strain resistant to pyrethroid and carbamate insecticides.
https://www.cabdirect.org/cabdirect/abstract/20133307487
Effects of juvenile hormone analog formulations on development and reproduction in the bed bug Cimex lectularius (Hemiptera: Cimicidae)
RESULTS: At 1× and 2× the label rate, Precor® [active ingredient (S)-methoprene] had no significant effect on the development or the ability to produce an abundance of offspring or new growth; of bed bugs. At 2× the label rate, confinement to residues of Gentrol® [active ingredient (S)-hydroprene] had no significant effect, but residues at 3× and 10× the label rate caused a reduction in fecundity and impaired development. http://onlinelibrary.wiley.com/doi/10.1002/ps.3376/full
Locomotion Inhibition of Cimex lectularius L. Following Topical, Sublethal Dose Application of the Chitin Synthesis Inhibitor Lufenuron.
The chitin synthesis inhibitor lufenuron had a significant effect on the ecdysis of fifth instar bed bugs to adult. The effective dose that resulted in 50% malformations and mortality (ED50)
There is no product labeled for bed bug use it’s the active ingredient in the dog chew in the veterinary flea control medication.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620714/
Juvenile hormone regulation of female reproduction in the common bed bug, Cimex lectularius
To begin studies on reproduction in common bed bug we identified 3 genes coding for a protein required for the reproductive success of insects and studied their hormonal regulation.
https://www.nature.com/articles/srep35546?WT.feed_name=subjects_rnai
Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius
Development of multifunctional metabolic synergists to suppress the evolution of resistance against pyrethroids in insects that blood feed on humans 3-Phenoxybenzyl hexanoate (PBH) was synthesized as a multifunctional pyrethroid synergist.
The addition of PBH to permethrin-treated females of the ISOP450 strain of Culex pipiens quinquefasciatus resulted in a threefold increase in synergism, as judged by the synergistic ratio. Similarly, PBH synergized the action of deltamethrin sixfold on females of the common bed bug, Cimex lectularius, and was 2.8-fold more synergistic than piperonyl butoxide (PBO).
http://onlinelibrary.wiley.com/doi/10.1002/ps.3856/full
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